[MCN] Review article: Microplastics' damaging effects on physiology, metabolism, neurology
lance at wildrockies.org
Tue Jan 29 10:30:25 EST 2019
Trends in Analytical Chemistry <https://www.sciencedirect.com/science/journal/01659936>. Volume 111 <https://www.sciencedirect.com/science/journal/01659936/111/supp/C>, February 2019, Pages 37-46
Ecotoxicological effects of microplastics: Examination of biomarkers, current state and future perspectives
Marko D.ProkićaTijana B.RadovanovićaJelena P.GavrićaCaterinaFaggiob <https://www.sciencedirect.com/science/article/abs/pii/S0165993618304710#!>
•Effects of microplastics depend on their size, dose and interaction.
•Accumulated microplastics can display variety of biological effects.
•Microplastics can induce oxidative stress and damage.
•Microplastics affect normal metabolism and cholinesterase activity.
•Microplastics can act as vector and modulate effects other xenobiotics.
Interest about interactions between microplastics and organisms is on the rise. Accessing organisms' responses to these chemically “inert” compounds plays an important role in determining their potential toxicity. Microplastics from the environment tend to accumulate and move through living organisms, inducing a variety of biological effects, such as disturbances in energy metabolism, oxidative balance, antioxidative <https://www.sciencedirect.com/topics/chemistry/antioxidant-agent> capacity, DNA, immunological, neurological and histological damage. In the present review, we summarized the adverse effects of different size, concentrations and types of microplastics on animals' antioxidative system, energy metabolism and nervous system. Results showed that microplastics can: induce oxidative damage (increased lipid peroxidation and DNA strand breaks); alter antioxidative system (superoxide dismutase, catalase <https://www.sciencedirect.com/topics/chemistry/catalase> and glutathione <https://www.sciencedirect.com/topics/chemistry/glutathione>peroxidase <https://www.sciencedirect.com/topics/chemistry/peroxidase> were parameters with the highest and significant changes in activities) and metabolism (isocitrate dehydrogenase and lactate <https://www.sciencedirect.com/topics/chemistry/lactate> dehydrogenase activity); and have neurotoxic <https://www.sciencedirect.com/topics/chemistry/neurotoxic> effects (inhibition of acetylcholinesterase activity). The effects were depending on size and dose of used microplastics, and/or their interaction with other xenobiotics <https://www.sciencedirect.com/topics/chemistry/xenobiotic-agent>. We examined also potential strategies and offer research priorities for current and future studies.
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